XIAP deficiency in hematopoietic recipient cells drives donor T-cell activation and GvHD in mice

Muller, N., Fischer, J.C., Yabal, M., Haas, T., Poeck, H., Jost, P.J. (2019). Eur J Immunol 49, 504-507.

DOI: 10.1002/eji.201847818(link is external)


Patients with X-linked lymphoproliferative syndrome type 2 (XLP-2) (BIRC4 deficiency) suffer from hyperinflammation often observed during the conditioning regimen prior to allogeneic bone marrow transplant. This article shows that in mice hematopoietic recipient cells contribute to graft-versus-host disease by the secretion of elevated levels of proinflammatory cytokines during engraftment when BIRC4 is absent.